CarF mediates signaling by singlet oxygen , generated via photoexcited 2 protoporphyrin

Versatile RBC-derived vesicles as nanoparticle vector of photosensitizers for photodynamic therapy.

Various nanocarriers for photosensitizers have been developed to solve the problems of limiting the clinical utility of photodynamic therapy (PDT); however, to date, no carriers capable of supplying oxygen have been reported. We reported the development of a novel system composed of red blood cell (RBC)-derived vesicles (RDVs) generated by osmotic stress and demonstrated the capacity of RDVs fo...

Protoporphyrin IX catalyzed hydrogen peroxide to generate singlet oxygen.

AIM To study the role of protoporphyrin IX (pPIX) in mitochondrial metabolism of hydrogen peroxide (H2O2). METHODS O2 (-) specific fluorescent markers DMA (9,10-dimerthylanthracence) and SOSG (Singlet Oxygen Sensor Green reagent) were used for measurement of singlet oxygen ((1)O2). Catalyzing conversion of H2O2 into (1)O2 by pPIX was monitored in vitro under varied H2O2 content, temperature, ...

Singlet Oxygen Chemistry in Water. 2. Photoexcited Sensitizer Quenching by O2 at the Waterâ‹TMPorous Glass Interface

Sinoporphyrin sodium, a novel sensitizer, triggers mitochondrial-dependent apoptosis in ECA-109 cells via production of reactive oxygen species

BACKGROUND Sonodynamic therapy (SDT) is a promising method that uses ultrasound to activate certain chemical sensitizers for the treatment of cancer. The purpose of this study was to investigate the sonoactivity of a novel sensitizer, sinoporphyrin sodium (DVDMS), and its sonotoxicity in an esophageal cancer (ECA-109) cell line. METHODS The fluorescence intensity of DVDMS, hematoporphyrin, pr...

ROLE OF Mn(TPP)Cl IN THE EPOXIDATION WITH SINGLET OXYGEN

Mn(TPP)Cl catalyzes cooxidation of olefin in the singlet oxygenation of sulfid. Mn(TPP)Cl is able to transfer an oxygen atom from a peroxidic intermediate generated in singlet oxygenation of sulfide to a metal ion affording metal 0x0 species which is responsible for epoxidation. This system leads to allcenes epoxidation such as styrene and cyclooctene. Epoxidation of cyclohexene produces cy...